The changes in production technology have the most direct influence on the teaching contents of vocational education. The changes in labor nature and production organization mode brought about by technological revolution have prescribed the qualitative specifications on the talents cultivated in vocational education. From the Taylorism of standardized production to the self-adaptive production mode in the era of AI, the ontological transformation of vocational education knowledge (vek) is reflected in the following aspects: technical orgware knowledge becomes the important foundation of vek; work process knowledge becomes the core element of vek; and technical purpose knowledge becomes the direction of vek. Epistemologically, it is mainly the transformation of knowledge growth: in the generation path, the bottom-up formation of skills will move to the top-down application of technoscience; in the way of distribution, class teaching system will move towards practice community; in the organizational environment, school-based teaching will move to workplace learning. The rational orientations of axiology will transform from “man-machine relationship” to “interpersonal relationship”; from “illusion of technology” to “consciousness of technology”; from “appliance craftsman” to “intelligent craftsman.”