In the late 1920s, the Great China University (private) began to introduce the tutorial system of Western universities to strengthen individual guidance for students and to get teachers and students more connected with each other. In the course of nearly 20 years of implementation, the Great China University incorporated the essence of the Western tutorial system with the cultural and educational traditions of China and its own characteristics, thus forming distinctive features in cultural connotation, system construction, educational practice and academic research. The tutorial system of the Great China University, as a classic case of the introduction and localization of the Western undergraduate teaching system by private universities in the Republic of China (1912-1949), not only shows the development process of modern higher education in China in transplanting and transforming overseas experience from one perspective, but also reveals the evolution law from tradition to modernity and from Westernization to Sinicization. It also has historical value and practical implication for the construction and improvement of the tutorial system of contemporary universities in China .