河北师范大学学报—

期刊信息

刊名：河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
主办：河北师范大学
ISSN： 1000-5854
CN： 13-1061/N
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光学纯2-氯丙酸的拆分研究

石家庄学院化工学院, 河北石家庄 050035
DOI：

Study on the Resolution of the Optical ly-active 2-chloropropionic Acid

ZHANG Baohua, SHI Lanxiang

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摘要/Abstract

摘要：

报道了使用光学纯的α-萘乙胺拆分外消旋2-氯丙酸制备(R)-(+)-2-氯丙酸和(S)-(-)-2-氯丙酸的新方法.(R)-(+)-2-氯丙酸收率28%,e.e.值97.2%,(S)-(-)-2-氯丙酸收率12%,e.e.值95.6%.适宜的拆分条件为异丙醇-水为溶剂,n((±)-2-氯丙酸))∶n(拆分剂)=1∶1,反应温度50℃.对(-)-α-萘乙胺和(+)-α-萘乙胺的回收使用进行了研究,回收率分别为70%和51%,重复使用5次,拆分效果不变.

Abstract：

A new method of preparing (R)-(+)-2-chloropropionic acid and (S)-(-)-2-chloropropionic acid by resolution with opt ically-act ive A-naphthylethylamine was reported.T he yields of (R)-(+)-2-chloropropinicacid and (S)-(-)-2-chloropropinic acid were up to 28 % and 12% respectively,the enant ioselectivities of them up to 97.2 % and 95.6 % respectively.T he opt imum resolving conditions were found as follow s:The resolution solvent,V ((CH₃) ₂CHOH)BV (H₂O) = 2:1 at the temperatur 50 e,n((?)-2-chloropropinic acid) Bn (resolving agent)=1B1.The reclaim of resolving agents were studied and their reclaim ratio were 70% and 51%,and their efficiency were unchanged after reusing 5 times.

关键词

关键词： 2-氯丙酸 ; (-)-&alpha ; -萘乙胺 ; (+)-&alpha ; -萘乙胺 ; (R)-(+)-2-氯丙酸 ; (S)-(-)-2-氯丙酸 ; 拆分

Key words： 2-chloropropinic acid ; (-)- A-naphthylethy lamine ; (+)- A-naphthylethylamine ; (R)-(+)-2-chloropropinic acid ; (S)-(-)-2-chloropropinic acid ; resolution