期刊信息
- 刊名： 河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
- 主办： 河北师范大学
- ISSN： 1000-5854
- CN： 13-1061/N
- 中国科技核心期刊
- 中国期刊方阵入选期刊
- 中国高校优秀科技期刊
- 华北优秀期刊
- 河北省优秀科技期刊
运动对骨形态发生蛋白6介导的机体铁代谢调节机制的研究进展
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1. 河北师范大学体育学院, ,河北 石家庄 050024;
2. 河南省开封县朱仙镇一中, 河南 开封 475131 -
DOI：
Regulatory Mechanism of Bone Morphogenetic Proteins 6 on Iron Metabolism During Exercise
摘要/Abstract
骨形态发生蛋白6(BMP6)为TGF-β超家族中一员,它产生于骨髓源性间质干细胞(BMSC)及造血干细胞,是一种调节成骨细胞和成软骨细胞分化的骨生长因子,在骨缺损的修复中具有重要作用.运动可促进BMP6的表达.研究发现,BMP6也是铁调素的重要的内源调节子,可以上调铁调素的表达,而铁调素是肠铁吸收的负调节子.因此,运动引起的BMP6表达增加,可以促进机体铁的吸收和释放,从而对运动中维持机体铁的动态平衡有重要的调控作用.
Bone morphogenetic protein 6(BMP6) is a member of the transforming growth factor-Mβ family,it is produced by bone marrow-mesenchymal(BMSC) and hematopoietic stem cells.BMP6is a potent protein for future treatment strategies of bone regeneration as it is a very important regulator of bone homeostasis and is a kind of adjusting the osteoblast and cartilage cells of bone growth factors.Moreover,it is also released by osteoclasts as a key bone coupling factor recruiting osteoblasts to the resorption site.So it has a good application potential in all kinds of bone defect repair.Sports can promote expression of BMP6.Recent study shows that BMP6can up-regulation of hepcidin expression.However,hepcidin is the negative regulators and down-regulation of intestinal iron absorbing.So exercise-induced increased expression of BMP6and promotes iron absorption and release.Consequently,to maintain iron homeostasis in the sport has an important regulatory role.