期刊信息
- 刊名： 河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
- 主办： 河北师范大学
- ISSN： 1000-5854
- CN： 13-1061/N
- 中国科技核心期刊
- 中国期刊方阵入选期刊
- 中国高校优秀科技期刊
- 华北优秀期刊
- 河北省优秀科技期刊
手性色谱固定相拆分手性药物坦索罗辛
-
1. 河北师范大学化学化工研究所, 河北石家庄050091;
2. 蚌埠医学院化学教研室, 安徽蚌埠233000) -
DOI：
Chiral Stationary Phase for Resolution of Tamsulosin Hydrochloride
摘要/Abstract
摘要：
采用天然手性中心多糖类手性反相色谱固定相填料,高氯酸钠水溶液和乙腈为流动相,在不同的流动相比例下拆分了手性药物坦索罗辛.研究了该化合物在不同条件下色谱参数变化的规律,包括保留时间、分离度、塔板数、半峰宽度、对称度等.得到了较好的拆分该手性化合物的色谱条件.
Abstract：
Using a natural polysaccharide-derived loading material as chiral stationary phase,sodium perchlorate solution and acetonit rile as mobile phase,racemic tamsulosin hydrochloride was separated by adjusting different proportion of mobile phase.TheHPLC parameters of this compound, including retention time,degree of separation,number of plates,half peak breadth,degree of symmet ry was studied in the different condition. The excel-lent condition of separation racemic tamsulosin hydrochloride was obtained.
关键词
Key words：
chiral stationary phase
;
chiral separation
;
tamsulosin