河北师范大学学报—

期刊信息

刊名：河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
主办：河北师范大学
ISSN： 1000-5854
CN： 13-1061/N
中国科技核心期刊
中国期刊方阵入选期刊
中国高校优秀科技期刊
华北优秀期刊
河北省优秀科技期刊

协同采编系统

友情链接

集成pH传感与防伪的双功能聚合物微阵列芯片

(江汉大学光电材料与技术学院，湖北省柔性显示材料与技术协同创新中心，湖北武汉 430056)
DOI： 10.13763/j.cnki.jhebnu.nse.202503016

Bifunctional polymer microarray chip integrating pH sensing and anti-counterfeiting

Zhou Jixiong,Ni Xiongzhi,Li Miaomiao,Gong Jingjing,Liu Xueqing,Liu Jiyan

PDF
下载
HTML

摘要/Abstract

摘要：

采用聚合物微阵列与高通量筛选技术，优选出丙烯酰胺聚合物作为功能基底，该基底可高效固定荧光素O-甲基丙烯酸酯.以该聚合物为基底，通过喷墨打印技术制备出集成pH响应型与光稳定型2类荧光染料的共聚物微阵列芯片.该芯片在pH=5、9的磷酸盐缓冲盐水（phosphate-buffered saline,PBS)中表现出显著的荧光响应特性，且具备优异的可逆性、可靠性与稳定性.基于上述特性，该芯片可用于构建信息加密图案，在特定pH刺激下实现“隐藏”与“显示”状态的可逆切换，从而实现动态多级防伪功能.本研究为开发兼具传感与显示双重性能的高安全性信息存储材料提供了有效策略.

Abstract：

Using polymer microarray and high-throughput screening technology，the functional substrate of acrylamide polymer was selected.This substrate enables the efficient immobilization of fluorescein O-methacrylate.Subsequently,a copolymer microarray chip integrating pH responsive and photostable fluorescent dyes was fabricated via inkjet printing using the as-prepared polymer substrate.The chip exhibited significant reversible fluorescence response characteristics in phosphate-buffered saline(PBS) with pH=5,9.And it has excellent reversibility,reliability and durability.Based on these characteristics,the chip was further applied to construct information encryption patterns that can reversibly switch between ″hidden″ and ″visible″ states through specific pH stimuli,thereby achieving dynamic anti-counterfeiting functionality.This study provides an effective strategy for developing high-security information storage materials with dual performance of sensing response and information display.

关键词

关键词： 聚合物微阵列；高通量筛选；喷墨打印；荧光传感；信息防伪

Key words： polymer microarray ; high-throughput screening ; inkjet printing ; fluorescent sensing ; information anti-counterfeiting

参考文献 32

[1] Gao Y Y,Yang Y H,Wei Y H,et al.Manipulating dynamic fluorescent emissions by introducing SP molecule into functionalized HOFs and application in time-resolved information encryption[J].Advanced Functional Materials,2025,35(9):2416025.DOI:10.1002/adfm.202416025.
[2] Mazzotta A,Gabbani A,Carlotti M,et al.Invisible thermoplasmonic indium tin oxide nanoparticle ink for anti-counterfeiting applications[J].ACS Applied Materials & Interfaces,2022,14(30):35276-35286.DOI:10.1021/acsami.2c10864.
[3] Wang C H,Hwang Y S,Wang H C,et al.Microstructure overlapping image application with optical decryption[J].Journal of the Optical Society of America A,2020,37(8):1361-1368.DOI: 10.1364/JOSAA.393182.
[4] Kim D,Kwon J E,Park S Y.Fully reversible multistate fluorescence switching:organogel system consisting of luminescent cyanostilbene and turn-on diarylethene[J].Advanced Functional Materials,2018,28(7):1706213.DOI:10.1002/adfm.201706213.
[5] Ge W Y,Zhang P F,Zhang X M,et al.Amorphous alumina:a bright red matrix for flexible and transparent anti-counterfeiting[J].ACS Sustainable Chemistry & Engineering,2021,9(30):10220-10226.DOI:10.1021/acssuschemeng.1c02541.
[6] Ko J,Ma K,Joung J F,et al.Ligand-assisted direct photolithography of perovskite nanocrystals encapsulated with multifunctional polymer ligands for stable,full-colored,high-resolution displays[J].Nano Letters,2021,21(5):2288-2295.DOI:10.1021/acs.nanolett.1c00134.
[7] Wang L,Liu G S,Wang Y C,et al.Transfer printing for fabrication of flexible RGB color e-paper[J].Journal of the Society for Information Display,2017,25(6):384-390.DOI:10.1002/jsid.562.
[8] [8]Lu X H,Li Z.Patterned microarrays or nanoscale assemblies for optical sensing of biomarkers[J].TrAC Trends in Analytical Chemistry,2024,179:117873.DOI:10.1016/j.trac.2024.117873.
[9] Chen X,He T,Jiang H W,et al.Screen-printing fabrication of electrowetting displays based on poly(imide siloxane) and polyimide[J].Displays,2015,37:79-85.DOI:10.1016/j.displa.2014.09.003.
[10] Li D,Yang Y J,Yang J,et al.Completely aqueous processable stimulus responsive organic room temperature phosphorescence materials with tunable afterglow color[J].Nature Communications,2022,13:347.DOI:10.1038/s41467-022-28011-6.
[11] Zang H M,Lin C,Du H,et al.Electrophoretic display comprising black,white,red,and yellow particles[J].Journal of the Society for Information Display,2022,30(5):387-394.DOI:10.1002/jsid.1121.
[12] Wang M,Jiang K K,Gao Y F,et al.A facile fabrication of conjugated fluorescent nanoparticles and micro-scale patterned encryption via high resolution inkjet printing[J].Nanoscale,2021,13(34):14337-14345.DOI:10.1039/d1nr03062k.
[13] Riexinger J,Caganek T,Wang X Z,et al.High-resolution patterned delivery of chemical signals from 3D-printed picoliter droplet networks[J].Advanced Materials,2025,37(28):2412292.DOI:10.1002/adma.202412292.
[14] Liu Z H,Huang J,Li Y J,et al.Synergistic physics-data-driven cross-scale optimization of dielectric properties in multimaterial inkjet printing[J].Additive Manufacturing,2025,109:104845.DOI:10.1016/j.addma.2025.104845.
[15] Jia S Q,Tang H D,Ma J R,et al.High performance inkjet-printed quantum-dot light-emitting diodes with high operational stability[J].Advanced Optical Materials,2021,9(22):2101069.DOI:10.1002/adom.202101069.
[16] Long Z S,Li H J,Cao Q L,et al.Large-scale synthesis of perovskite quantum dots and their application to inkjet-printed highly stable microarray[J].Small,2025,21(15):2410935.DOI:10.1002/smll.202410935.
[17] Paul A A,Kryukov O,Bandela A K,et al.Development of covalently functionalized alginate-pyrrole and polypyrrole-alginate nanocomposites as 3D printable electroconductive bioinks[J].Materials,2025,18(13):3120.DOI:10.3390/ma18133120.
[18] Li J S,Tan Q H,Li J Y,et al.Helical coassembly enables full-color efficient circularly polarized light emission from carbon dots with high dissymmetry factors[J].Science Advances,2025,11(20):eadt8219.DOI:10.1126/sciadv.adt8219.
[19] Zhang T L,Zhao C X,Liu Z J,et al.Reversible acid-base responsive fluorescence changes of solutions and crystals based on anthracenyl pyridyl derivatives[J].ChemPhotoChem,2023,7(11):e202300194.DOI:10.1002/cptc.202300194.
[20] Hazra N,Paul S,Hazra S,et al.An aggregation-induced change in the fluorescence of carbon dots:naked eye water detection in a selective organic solvent[J].ChemistrySelect,2023,8(28):e202301260.DOI:10.1002/slct.202301260.
[21] Sun Z C,Xu Z J,Wu P C,et al.Dual-responsive ultrathin polymersomes with reversible transitions on acidochromism and fluorochromism performances for multiple information encryption[J].Angewandte Chemie International Edition,2025,64(30):e202507852.DOI:10.1002/anie.202507852.
[22] Duffy C R E,Zhang R,How S E,et al.A high-throughput polymer microarray approach for identifying defined substrates for mesenchymal stem cells[J].Biomaterials Science,2014,2(11):1683-1692.DOI:10.1039/c4bm00112e.
[23] Gong J J,Venkateswaran S,Tanner M G,et al.Polymer microarrays for the discovery and optimization of robust optical-fiber-based pH sensors[J].ACS Combinatorial Science,2019,21(5):417-424.DOI:10.1021/acscombsci.9b00031.
[24] Xia H Y,Ding Y G,Gong J J,et al.Programmable and flexible fluorochromic polymer microarrays for information sto-rage[J].ACS Applied Materials & Interfaces,2022,14(23):27107-27117.DOI:10.1021/acsami.2c02242.
[25] Xia H Y,Loan T,Santra M,et al.Multiplexed stimuli-responsive molecules for high-security anti-counterfeiting applications[J].Journal of Materials Chemistry C,2023,11(12):4164-4170.DOI:10.1039/d2tc05404c.
[26] Gong J J,Tanner M G,Venkateswaran S,et al.A hydrogel-based optical fibre fluorescent pH sensor for observing lung tumor tissue acidity[J].Analytica Chimica Acta,2020,1134:136-143.DOI:10.1016/j.aca.2020.07.063.
[27] Wang G R,Duan Z Q,Sheng Y,et al.Tuning the emission properties of a fluorescent polymer using a polymer microarray approach-identification of an optothermo responsive polymer[J].Chemical Communications,2016,52(69):10521-10524.DOI:10.1039/c6cc04657f.
[28] Zhang R,Liberski A,Sanchez-Martin R,et al.Microarrays of over 2 000 hydrogels-identification of substrates for cellular trapping and thermally triggered release[J].Biomaterials,2009,30(31):6193-6201.DOI:10.1016/j.biomaterials.2009.07.055.
[29] 吴雨晨,陈浩,朱良宇,等.丙烯酰胺和N,N-二甲基丙烯酰胺反相乳液共聚动力学[J].功能高分子学报,2024,37(4):332-337.DOI:10.14133/j.cnki.1008-9357.20240319003. Wu Yuchen,Chen Hao,Zhu Liangyu,et al.Kinetics of inverse emulsion copolymerization of acrylamide and N,N-dimethylacrylamide[J].Journal of Functional Polymers,2024,37(4):332-337.
[30] 李雅欣,谢俊龙,李成豪,等.紫外光固化PAA-PAM共聚水凝胶的制备及性能研究[J].中国塑料,2025,39(7):22-27.DOI:10.19491/j.issn.1001-9278.2025.07.005. Li Yaxin,Xie Junlong,Li Chenghao,et al.Preparation and properties of UV-curable PAA-PAM copolymer hydrogels[J].China Plastics,2025,39(7):22-27.
[31] Cao X,Lv R L,Wei Y.Cationic carbon dot reinforced highly tensile,tough,dehydration resistant polyelectrolyte hydrogels with fluorescence for flexible sensing and information anti-counterfeiting[J].Small,2025,21(29):2501531.DOI:10.1002/smll.202501531.
[32] Wang Y Y,Wu S G.High-performance green fluorescent carbon dots:synthesis,properties,and applications in temperature sensing,and information anti-counterfeiting[J].Materials Science and Engineering:B,2025,319:118355.DOI:10.1016/j.mseb.2025.118355.