河北师范大学学报—

期刊信息

刊名：河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
主办：河北师范大学
ISSN： 1000-5854
CN： 13-1061/N
中国科技核心期刊
中国期刊方阵入选期刊
中国高校优秀科技期刊
华北优秀期刊
河北省优秀科技期刊

协同采编系统

友情链接

果蝇Toll受体和Spätzle因子在中枢神经系统中的功能研究进展

(华南农业大学动物科学学院,广东省蚕桑工程技术研究中心,广州 510642)
DOI： 10.13763/j.cnki.jhebnu.nse.202504014

Advances in the Functional Research of Drosophila Toll Receptors and Cytokine Spätzle in Central Nervous System

HONG Min,HU Yingying,HE Na,YI Huiyu,YANG Wanying

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摘要/Abstract

摘要：

果蝇基因组共编码9个Toll受体和6个细胞因子Spätzle.经典的果蝇Toll信号通路依赖于Spätzle因子的激活，进而参与调控果蝇的先天免疫应答及胚胎早期背腹轴的形成.此外，越来越多的研究表明，Toll受体家族成员在果蝇中枢神经系统（central nervous system,CNS）的形成、发育以及稳态维持过程中发挥重要作用.在果蝇胚胎发生过程中，中枢神经系统中约有一半的神经元经历程序性死亡，而Toll受体及其配体Spätzle因子在中枢神经系统的形成、神经元存活的调控、结构可塑性维持以及细胞稳态中均具有关键功能.重点综述了果蝇Toll受体家族、Spätzle因子家族及其介导的Toll-Spätzle信号通路在中枢神经系统中的功能研究进展，以期为深入探讨Toll信号通路在果蝇神经系统中的生物学作用提供理论依据.

Abstract：

The Drosophila melanogaster genome encodes a total of nine Toll receptors and six Spätzle cytokines.The canonical Drosophila Toll signaling pathway relies on the activation of cytokine Spätzle and is involved in regulating the innate immune responses as well as the establishment of the dorsoventral axis during early embryogenesis.Additionally,a growing body of research demonstrates that members of the Toll receptor family play crucial roles in the formation,development,and maintenance of homeostasis in the central nervous system(CNS) of Drosophila.During Drosophila embryogenesis,approximately half of the neurons in the central nervous system undergo programmed cell death,whereas Toll receptors and their ligands Spätzle exert key functions in CNS patterning,the regulation of neuronal survival,the maintenance of structural plasticity,and cellular homeostasis.This review focuses on recent advances in understanding the roles of the Drosophila Toll receptor family,the Spätzle family,and the Toll-Spätzle signaling pathway they mediate in the central nervous system,aiming to provide a theoretical foundation for further elucidating the biological functions of Toll signaling in the Drosophila nervous system.

关键词

关键词： 果蝇；中枢神经系统； Toll受体； Spätzle因子 ; Toll-Spätzle通路

Key words： Drosophila ; central nervous system ; Toll receptors ; Spätzle ; Toll-Spätzle pathway

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