期刊信息
- 刊名： 河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
- 主办： 河北师范大学
- ISSN： 1000-5854
- CN： 13-1061/N
- 中国科技核心期刊
- 中国期刊方阵入选期刊
- 中国高校优秀科技期刊
- 华北优秀期刊
- 河北省优秀科技期刊
三组分串联反应合成多环稠合1,5-苯并氧氮杂䓬化合物
- （河北师范大学 化学与材料科学学院，河北省有机功能分子重点实验室，石家庄 050024）
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DOI：10.13763/j.cnki.jhebnu.nse.202503002
Synthesis of Polycyclic Fused 1,5-benzoxazepine Compounds by Three-component Tandem Reaction
摘要/Abstract
以邻氨基苯酚、β-环状二酮、芳香醛为原料，无水乙醇为溶剂，对甲苯磺酸为催化剂，通过三组分串联反应一锅合成了5种新型的多环稠合1,5-苯并氧氮杂䓬化合物.该串联反应实现了在一个反应体系中构建同时含有O，N杂原子的七元环和4个新化学键（C—O，C—N，C—C和C—C），并提出了2种可能的反应机理.该方法具有反应条件温和、绿色环保、操作简单、产率优良等优点，为多环稠合1,5-苯并氧氮杂䓬化合物的制备提供了新的参考方法.
Using o-aminophenol,β-cyclic diketones and aromatic aldehydes as raw materials,anhydrous ethanol as solvent,and p-toluenesulfonic acid as catalyst,five new types of polycyclic 1,5-benzoxazepines were synthesized by one-pot three-component tandem reaction.This tandem reaction achieved the synthesis of seven-membered rings containing both oxygen and nitrogen heteroatoms,along with four new chemical bonds(C—O,C—N,C—C and C—C) in a reaction system.Additionally,two possible reaction mechanisms were proposed.This method has advantages including simple and mild reaction conditions,environmental friendliness,and high yields,which provides a novel reference for the synthesis of polycyclic 1,5-benzoxazepine compounds.
关键词
参考文献 13
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