期刊信息
- 刊名: 河北师范大学学报(自然科学版)Journal of Hebei Normal University (Natural Science)
- 主办: 河北师范大学
- ISSN: 1000-5854
- CN: 13-1061/N
- 中国科技核心期刊
- 中国期刊方阵入选期刊
- 中国高校优秀科技期刊
- 华北优秀期刊
- 河北省优秀科技期刊
Progress on the Synthesis of 3-norcephalosporin
摘要/Abstract
摘要:
3-正头孢化合物是合成头孢布烯和头孢唑肟的重要中间体。介绍了以青霉素G为原料分别经3-羟基头孢烯、丙二烯氮杂环丁酮中间体的盐野义和大路线,以及以头孢菌素C为原料经3-环外亚甲基中间体的Schering合成路线,并对各条工艺路线进行了评价。
Abstract:
3-norcephalosporin compounds are important intermediate for the manufacture of ceftibuten and ceftizoxime.This article reviews the recent progress in the synthesis of 3-norcephalosporin including Shionogi route via 3-hydroxycephem and Otsuka route via allenecarboxyate intermediate from penicillin G,and Schering rote via 3-exomethene intermediate based on cephalosporin C.
关键词
关键词:
青霉素G钾
;
头孢菌素C,3-羟基头孢烯
;
丙二烯氮杂环丁酮
;
3-环外亚甲基
;
3-正头孢化合物
Key words:
penicillin G
;
cephalosporin C
;
3-hydroxycephem
;
allenecarboxyate
;
3-exomethene
;
3-nor-cephalosporin