期刊信息

  • 刊名： 河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
  • 主办： 河北师范大学
  • ISSN： 1000-5854
  • CN： 13-1061/N
  • 中国科技核心期刊
  • 中国期刊方阵入选期刊
  • 中国高校优秀科技期刊
  • 华北优秀期刊
  • 河北省优秀科技期刊

协同采编系统

友情链接

阿尔茨海默病的发病机制及治疗新进展

  • (1.河北师范大学 生命科学学院，河北 石家庄 050024； 2.健垣科技石家庄有限公司，河北 石家庄 050000)
  • DOI： 10.13763/j.cnki.jhebnu.nse.202404011

Recent Advances in Pathogenesis and Treatment of Alzheimer′s Disease

摘要/Abstract

摘要：

阿尔茨海默病(Alzheimer′s disease,AD)是一种进行性神经退行性疾病，也是痴呆症的主要原因.关于AD发病机制的假说很多，包括Aβ假说、Tau蛋白假说、胆碱能假说、神经炎症假说、线粒体功能障碍以及氧化应激假说等.概述了AD的主要生物学发病机制，并讨论了其治疗新进展.由于病理生理的复杂性，AD治疗可能需要多模式协同方案，因此，深讨了从传统治疗转向新兴治疗策略的研究进展.

Abstract：

Alzheimer′s disease(AD)is a progressive neurodegenerative disease and the most important cause of dementia.There are many hypotheses about AD pathogenesis,including Aβ hypothesis,Tau protein hypothesis,cholinergic hypothesis,neuroinflammation hypothesis,mitochondrial dysfunction and oxidative stress hypothesis.This article summarizes the six major mechanisms of the main biological pathogenesis of AD,and discusses the new progress in its treatment.Due to the complexity of the pathophysiology of AD,multimodal synergistic treatment may be required.This paper show the research progress of the shift from traditional treatment to emerging treatment strategies.

关键词

关键词： 阿尔茨海默病； 发病机制； 治疗
Key words： Alzheimer′s disease ; pathogenesis ; treatment

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