期刊信息

  • 刊名： 河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
  • 主办： 河北师范大学
  • ISSN： 1000-5854
  • CN： 13-1061/N
  • 中国科技核心期刊
  • 中国期刊方阵入选期刊
  • 中国高校优秀科技期刊
  • 华北优秀期刊
  • 河北省优秀科技期刊

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金属基纳米材料介导的肿瘤化学动力学治疗研究进展

  • （河北师范大学 生命科学学院，河北 石家庄 050024）
  • DOI： 10.13763/j.cnki.jhebnu.nse.202304013

Research Progress in Tumor Chemodynamic Therapy Mediated by Metal-based Nanomaterials

摘要/Abstract

摘要：

化学动力疗法（chemodynamic therapy，CDT）是一种利用肿瘤微环境（tumor microenvironment，TME）弱酸、H2O2和GSH过量等特点，通过金属离子介导的芬顿或类芬顿反应，将内源性H2O2转化为高度细胞毒性的羟基自由基（·OH）来杀伤肿瘤细胞的方法.这种治疗方法因其侵袭性小、肿瘤特异性高而得到了广泛的研究，在肿瘤治疗方面显示出很好的治疗潜力.目前，已经开发了多种基于金属离子的纳米催化剂用于CDT，如Fe2+，Cu+，Mn2+，Ce3+等.对这几种常见的金属基纳米催化剂在CDT中的应用进行了综述，并对CDT面临的挑战和未来的发展趋势进行了讨论.

Abstract：

Chemodynamic therapy (CDT) is a method to kill tumor cells by transforming endogenous H2O2 into highly cytotoxic hydroxyl radicals (·OH) through metal ion-mediated Fenton or Fenton-like reactions，making use of the characteristics of excessive weak acid，H2O2 and GSH in tumor microenvironment (TME). This treatment has been widely studied because of its low invasiveness and high tumor specificity，and has shown good therapeutic potential in tumor treatment. At present，a variety of metal ion-based nanocatalysts have been developed for CDT，such as Fe2+，Cu+，Mn2+，Ce3+ and so on. In this paper，the applications of these common metal-based nanocatalysts in CDT are reviewed，and the challenges and future development trends of CDT are discussed.

关键词

关键词： 化学动力疗法（CDT）； 芬顿/类芬顿反应； 纳米催化剂； 肿瘤治疗
Key words： chemodynamic therapy (CDT) ; Fenton/Fenton-like reaction ; nanocatalyst ; cancer treatment

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