河北师范大学学报—

期刊信息

刊名：河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
主办：河北师范大学
ISSN： 1000-5854
CN： 13-1061/N
中国科技核心期刊
中国期刊方阵入选期刊
中国高校优秀科技期刊
华北优秀期刊
河北省优秀科技期刊

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果糖-1, 6-二磷酸醛缩酶的研究进展

（河北师范大学生命科学学院，河北石家庄 050024）
DOI： 10.13763/j.cnki.jhebnu.nse.202204006

Research Progress of Fructose-1, 6-bisphosphate Aldolase

XIAO Shuwen, HU Yonghong

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摘要/Abstract

摘要：

果糖-1, 6-二磷酸醛缩酶（FBA）是糖酵解途径中一种重要的生物酶，可催化底物果糖-1, 6-二磷酸裂解为3磷酸甘油醛和磷酸二羟丙酮或反向的醛醇缩合反应.主要介绍了FBA的分类及其功能，如参与生物体内代谢、充当纤溶酶原结合蛋白、作为宿主细胞粘附结合剂、转录调节因子等，并总结了FBA在抗真菌药物靶点、抗病原体疫苗方面的应用，旨在为后续FBA的深入研究提供基础资料.

Abstract：

Fructose-1, 6-bisphosphate Aldolase (FBA) is an important biological enzyme in the glycolysis pathway.It catalyzes the cleavage of the substrate fructose-1, 6-bisphosphate into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate or the reverse aldol condensation reaction.In this article, we mainly introduced the classification of FBA and its function, such as participation in the metabolism of organisms, as a plasminogen binding protein, as a host cell adhesion binding agent, transcription regulator and so on.Moreover, the application of FBA in anti-fungal drug targets and anti-pathogen vaccines were also summarized.Therefore, this article aims to provide basic information for the in-depth research of FBA in the future.

关键词

关键词： 果糖-1, 6-二磷酸醛缩酶；分类；生理功能；药物靶点；候选疫苗

Key words： FBA ; classification ; physiological function ; drug target ; candidate vaccine

参考文献 45

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