期刊信息

  • 刊名： 河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
  • 主办： 河北师范大学
  • ISSN： 1000-5854
  • CN： 13-1061/N
  • 中国科技核心期刊
  • 中国期刊方阵入选期刊
  • 中国高校优秀科技期刊
  • 华北优秀期刊
  • 河北省优秀科技期刊

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一种含精氨酸和抗氧化成分的胶囊对 糖尿病小鼠糖脂代谢改善作用的研究

  • （河北师范大学 生命科学学院，河北 石家庄050024）
  • DOI： 10.13763/j.cnki.jhebnu.nse.202204001

One Kind of Capsule Containing Arginine and Antioxidants Ameliorated the Disorders of Glucose and Lipid Metabolism in Diabetic Mice

摘要/Abstract

摘要：

用含有精氨酸和多种抗氧化剂成分的纳欧胶囊溶液对小鼠进行灌胃，灌胃不同剂量的胶囊1个月后制备糖尿病小鼠模型.结果表明，纳欧胶囊能显著降低小鼠空腹血糖、糖耐量、总胆固醇、血清铁水平；下丘脑转铁蛋白受体1和铁蛋白表达无显著变化,肝脏转铁蛋白受体1表达呈下降趋势；糖尿病小鼠出现了胰岛素抵抗，纳欧胶囊对胰岛素抵抗指数无明显影响.纳欧胶囊对糖尿病小鼠具有辅助降血糖、降血脂及降低血清铁的作用，这可对临床上预防和治疗高血糖疾病提供动物实验数据和理论支持.

Abstract：

In this study,mice are intragastrically administrated with a “NO capsule” solution containing arginine and multiple antioxidants with different doses for one month,and diabetes mouse models are subsequently prepared.Results show that “NO capsule” significantly reduce the levels of fasting bloodglucose,glucose tolerance,total cholesterol,and serum iron in diabetic mice.No significant changes are observed for transferrin receptor 1 and ferritin expression in hypothalamus,but transferrin receptor 1 in liver shows a declined trend.Data also show that diabetic mice develop insulin resistance,and “NO capsule” has no obvious effect on insulin resistance index (IRI).The results suggest that “NO capsule” can attenuate the high level of blood glucose,lipid and serum iron in diabetic mice,which provides animal experimental data and theoretical basis for prevention and treatment of hyperglycemia in clinical.

关键词

关键词： 糖尿病； 纳欧胶囊； 血糖； 胆固醇； 铁
Key words： diabetes ; NO capsule ; blood glucose ; cholesterol ; iron

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