期刊信息

  • 刊名： 河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
  • 主办： 河北师范大学
  • ISSN： 1000-5854
  • CN： 13-1061/N
  • 中国科技核心期刊
  • 中国期刊方阵入选期刊
  • 中国高校优秀科技期刊
  • 华北优秀期刊
  • 河北省优秀科技期刊

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苯并氮杂环类化合物的绿色合成研究进展

  • 河北师范大学 化学与材料科学学院, 河北 石家庄 050024
  • DOI： 10.13763/j.cnki.jhebnu.nse.2019.03.009

Progress in Green Synthesis of Benzazepines

摘要/Abstract

摘要：

苯并氮杂环化合物以其特殊的结构特点和广泛的生理及药理活性而备受关注，也是医药、化学品及功能化材料的基本原料或关键中间体，因此其绿色合成方法的研究是有机化学及药学领域的研究热点之一.苯并五元、六元、七元氮杂环化合物通常是由邻氨基苯酚（硫酚、二胺）与不同结构的羰基化合物反应制得，本文中，笔者阐述了近年来苯并五元、六元、七元氮杂环化合物的绿色合成方法的研究进展，归纳、整理、总结各类反应的特点和优势，并展望了其合成及应用的前景.

Abstract：

Benzazepines have attracted much attention due to their special structural characteristics and extensive physiological and pharmacological activities.They are also the basic raw materials or key intermediates for pharmaceuticals,chemicals and functional materials.Therefore,the research on its green synthesis method is one of the research hotspots in the field of organic chemistry and pharmacy.And this paper elaborated the process of successfully synthesizing various 5-,6- and 7-benzazepines by nucleophilic reactions of o-aminobenzenephenol (thiol,diami) with carbonyl compounds,promoting the development of the modern green synthesis method of benzazepines.The application prospect on green synthesis of benzazepines is also discussed.

关键词

关键词： 苯并氮杂环 ; 绿色合成 ; 研究进展
Key words： benzazepines ; green synthesis ; progress

参考文献 36

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