期刊信息
- 刊名： 河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
- 主办： 河北师范大学
- ISSN： 1000-5854
- CN： 13-1061/N
- 中国科技核心期刊
- 中国期刊方阵入选期刊
- 中国高校优秀科技期刊
- 华北优秀期刊
- 河北省优秀科技期刊
Asymmetric Reduction of Aliphatic Ketone by 1,2,5,6-di-isopropylidenemannitol Modified Lithium Aluminum Hydride Reagents
摘要/Abstract
摘要：
利用手性一元醇作辅助配体, 与1, 2, 5, 6二丙酮甘露醇共同修饰LiAlH4对脂肪酮进行对映选择还原, 得到光学活性产物8个, 通过与α乙酰氧基l丙酰氯作用生成非对映异构体酯, 经气相色谱分析, 光学产率为2.7%～30%.
Abstract：
Lithium aluminum hydride modified with 1,2,5,6-di-isopropylidenemannitol and other chiral alcohols was applied to reduce aliphatic ketones to yield their corresponding optically active alcohols which were converted to their diastereoisomers withactyl-1-propiony l chloride. Gas chromatography quantitative analysis showed that the optical yields of asymmetric reduction of aliphatic ketone fell between 2.7%～30%.
关键词
Key words：
modification chiral alcohol
;
a symmetric reduction
;
diastereoismer