期刊信息
- 刊名： 河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
- 主办： 河北师范大学
- ISSN： 1000-5854
- CN： 13-1061/N
- 中国科技核心期刊
- 中国期刊方阵入选期刊
- 中国高校优秀科技期刊
- 华北优秀期刊
- 河北省优秀科技期刊
新型抗癫痫药普瑞巴林的拆分工艺优化
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1. 河北化工医药职业技术学院 制药工程系, 河北 石家庄 050026;
2. 河北科技大学 化学与制药工程学院, 河北 石家庄 050018 -
DOI：10.13763/j.cnki.jhebnu.nse.2017.06.010
Improved Resolution Process of a New Antiepileptic Drug Pregabalin
摘要/Abstract
摘要：
使用自制拆分剂对甲苯磺酰胺基-D-苯甘氨酸拆分新型抗癫痫药普瑞巴林的外消旋体，拆分率约为40%，以 3-（氨甲酰甲基）-5-甲基己酸为原料制备S-普瑞巴林的总收率为31.95%.
Abstract：
A new chiral resolution agents of (4-methyl phenyl) sulfonyl amino-D-benzeneacetic acid was disclosed to obtain a new antiepileptic drug S-pregabalin.The yield was 40% and the total percent recovery from 3-(carbamoylmethyl)-5-methylhexanoic acid was 31.95%.
关键词
关键词：
抗癫痫药
;
普瑞巴林
;
拆分工艺
;
对甲苯磺酰胺基-D-苯甘氨酸
参考文献 9
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- [2] ZHENG Renchao,WANG Tianzhen,FU Dejin,et al.Biocatalytic Synthesis of Chiral Intermediate of Pregabalin with High Substrate Loading by a Newly Isolated Morgarella Morganii ZJB-09203[J].Applied Microblology and Biotechnology,2013,97(11):4839-4847.doi:10.1007/s00253-013-4810-4
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- [9] 张静,付德才.新型抗癫痫药普瑞巴林的合成工艺优化[J].河北师范大学学报(自然科学版),2017,41(4):329-333.doi:10.13763/j.cnki.jhebnu.nse.2017.04.010