期刊信息
- 刊名： 河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
- 主办： 河北师范大学
- ISSN： 1000-5854
- CN： 13-1061/N
- 中国科技核心期刊
- 中国期刊方阵入选期刊
- 中国高校优秀科技期刊
- 华北优秀期刊
- 河北省优秀科技期刊
1-三十烷醇的合成工艺改进
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1. 河北科技大学 化学与制药工程学院, 河北 石家庄 050018;
2. 河北省药用分子化学重点实验室-省部共建国家重点实验室培育基地, 河北 石家庄 050018;
3. 衡水市冀州区瑞天生物科技有限公司, 河北 衡水 053200 -
DOI：10.13763/j.cnki.jhebnu.nse.2017.04.011
Improvement on the Synthetically Process of 1-triacontanol
摘要/Abstract
1-三十烷醇是一种有效的植物生长调节剂.设计了一条新的1-三十烷醇的合成路线，以1，12-十二烷二醇和溴代十八烷为起始原料，通过选择性保护羟基、选择性氧化伯醇成醛、十八烷基三苯基溴化膦盐制备、维悌希反应和加氢还原等5步化学反应，制备得到1-三十烷醇，重结晶后产品纯度在98%以上.
1-triacontanol is an efficient plant growth regulator.In this paper,a new organic synthetic process was designed to prepare 1-triacontanol through 5-step reactions,starting from 1,12-dodecanediol and octadecyl bromide.One hydroxyl group of 1,12-dodecanediol was selectively protected by TBDMSCl,and the other one was oxidized to get 12-tert-butyl dimethyl silanyloxydodecanal.Octadecyl bromide reacted with triphenyl phosphonium to get octadecyl triphenyl phosphonium bromide.Wittig reaction was carried out with the two intermediates.The product (olefin) was reduced by hydrogen and then the protective group TBDMS was removed to yield 1-triacontanol.After recrystalization,the GC purity of 1-triacontanol was over 98 percent.
关键词
参考文献 15
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