河北师范大学学报—

期刊信息

刊名：河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
主办：河北师范大学
ISSN： 1000-5854
CN： 13-1061/N
中国科技核心期刊
中国期刊方阵入选期刊
中国高校优秀科技期刊
华北优秀期刊
河北省优秀科技期刊

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铁脂质体的制备及其体外释放研究

李妮娜¹

李亚永²

王琳¹

常彦忠³

耿丽娜¹

1. 河北师范大学化学与材料科学学院, 河北石家庄 050024;
2. 石家庄市第一医院内科, 河北石家庄 050000;
3. 河北师范大学生命科学学院, 河北石家庄 050024
DOI： 10.13763/j.cnki.jhebnu.nse.2017.01.011

Preparation and in Vitro Release Study of Iron Liposomes

LI Nina¹, LI Yayong², WANG Lin¹, CHANG Yanzhong³, GENG Lina¹

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摘要/Abstract

摘要：

铁是人体必需的微量元素之一，铁缺乏会导致贫血等疾病，而常规补铁剂具有吸收率低、有毒性等缺点.采用薄膜旋转蒸发法和乙醇注入法，成功制备了柠檬酸铁脂质体（FAC-lip）和血红素铁脂质体（HEME-lip）.采用动态光散射（DLS）、透射电镜（TEM）对铁脂质体进行了表征，并进行体外释放研究.结果表明，铁脂质体都呈球形、具有连续膜结构和缓释性，且药物的分子量、结构、与膜层作用力及脂质体的粒径大小对脂质体的药物释放都有影响.

Abstract：

Iron is one of the essential trace elements of all organisms and iron deficiency can lead to anemia,but the conventional iron agents have many disadvantages,such as low efficacy and certain toxicity.In this study,ferric citrate liposomes (FAC-lip) and heme liposomes (HEME-lip) are prepared successfully by rotary-evaporated film-ultrasonication method and ethanol injection method.The prepared iron liposomes are characterized by dynamic light scattering (DLS) and transmission electron microscope (TEM) and studied the release in vitro.The results showed that iron liposomes are all spherical shape and had continous membranes.Meanwhile,the iron liposomes have controlled-release properties,and the molecular mass and structure of drugs and the particle sizes of liposomes all can affect the release in vitro.

关键词

关键词： 柠檬酸铁 ; 血红素铁 ; 脂质体 ; 体外释放 ; 缓释性

Key words： FAC ; HEME ; liposome ; release in vitro ; control release

参考文献 18

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