期刊信息

  • 刊名： 河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
  • 主办： 河北师范大学
  • ISSN： 1000-5854
  • CN： 13-1061/N
  • 中国科技核心期刊
  • 中国期刊方阵入选期刊
  • 中国高校优秀科技期刊
  • 华北优秀期刊
  • 河北省优秀科技期刊

协同采编系统

友情链接

骨微损伤与竞技运动的研究进展

  • 河北师范大学 体育学院, 河北 石家庄 050024
  • DOI： 10.13763/j.cnki.jhebnu.nse.2016.02.016

Research Progress on Relationship of Bone Microdamage and Competitive Sports

摘要/Abstract

摘要：

骨在重复载荷作用下会发生疲劳,疲劳又会引起骨的微损伤,这是一种由骨功能下降到骨结构改变的生理向病理发展过程.这一阶段的微损伤是仅在显微镜下能观察到骨基质的损伤.这一过程如能及时调整,通过自身反馈机制可进行修复和适应性重建以促进骨结构与骨功能的提高;若微损伤反复积累,可导致重建障碍继而诱发骨裂或骨折.骨的微损伤是近年来学界关注的一个问题,但与之运动相关的研究报道较少.本文以近年来的文献为资料,就骨微损伤的种类、损伤与修复机制、易发生部位、检测方法、生化评价以及药物治疗的研究现状进行综述.结合运动实践探讨骨微损伤的研究思路和方法应用,为运动性骨疲劳积累而引起的骨损伤及其防治提供参考.

Abstract：

The bone fatigue appears under the repeated loads,and may cause bone microdamage.This which is a development process from physiology to pathology of the bone function and bone structure.The bone microdamage in this stage is bone matrix damage,which can only be observed by microscope.If promptly adjusting the play in this process,feedback mechanism by repairing and rebuilding can promote adaptive bone structure and bone function.Otherwise the repeated microdamage accumulation can lead to rebuilding obstacles and then induce fractures.The bone microdamage is one of the focused medical field,but the sports-related research report is less.The recent development in the bone microdamage is briefly reviewed,including the microdamage types,injury and repair mechanisms,easily injured positions,detection methods,biochemical evaluation and drug treatment.Combined with exercise practice the research methods of bone microdamage,this paper can provide reference for the prevention and treatment of the bone damage caused by bone fatigue accumulation.

关键词

关键词： 骨疲劳 ; 骨微损伤 ; 超负荷运动 ; 损伤积累 ; 应力性骨折
Key words： bone fatigue ; bone micro-damage ; overloaded exercise ; damage accumulation ; stress fracture

参考文献 41

  • [1] DIAB T,VASJISHTH D.Effect of Damage Morphology on Cortical Bone Fragility[J].Bone,2005,37(1):96-102.doi: 10.1016/j.bone.2005.03.014
  • [2] DIAB T,CONDON K W,BURR D B,et al.Age-related Change in the Damage Morphology of Human Cortical Bone and its Role in Bone Fragility[J].Bone,2006,38(3):427-431.
  • [3] O'BRIEN F J,TAYLOR D,LEE T C.The Effect of Bone Microstructure on the Initiation and Growth of Microcracks[J].Journal of Orthopaedic Research,2005,23(2):475-480.doi: 10.1016/j.orthres.2004.08.005
  • [4] FOLLET H,FARLAY D,BALA Y,et al.Determinants of Microdamage in Elderly Human Vertebral Trabecular Bone[J].PLOS ONE,2013,8(2):e55232.doi:10.1371/journal.pone.0055232
  • [5] EHRLICH P J,NOBLE B S,JESSOP H L,et al.The Effect of in Vivo Mechanical Loading on Estrogen Receptor Alpha Expression in Rat Ulnar Osteocytes[J].J Bone Miner Res,2002,17(9):1646-1655.
  • [6] MULCAHY L E,TAYLOR D,LEE T C,et al.RANKL and OPG Activity is Regulated by Injury Size in Networks of Osteocyte-like Cells[J].Bone,2011,48(2):182-188.doi: 10.1016/j.bone.2010.09.014
  • [7] HEINO T J,KURATA K,HIGAKI H,et al.Evidence for the Role of Osteocytes in the Initiation of Targeted Remodeling[J].Technol Health Care,2009,17(1):49-56.doi: 10.3233/THC-2009-0534
  • [8] KOGIANNI G,MANN V,NOBLE B S.Apoptotic Bodies Convey Activity Capable of Initiating Osteoclastogenesis and Localized Bone Destruction[J].J Bone Miner Res,2008,23(6):915-927.doi: 10.1359/jbmr.080207
  • [9] CARDOSO L,HERMAN B C,VERBORGT O,et al.Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue[J].J Bone Miner Res,2009,24(4):597-605.doi: 10.1359/jbmr.081210
  • [10] KENNEDY O D,HERMAN B C,LAUDIER D M,et al.Activation of Resorption in Fatigue-loaded Bone Involves Both Apoptosis and Active Pro-osteoclastogenic Signaling by Distinct Osteocyte Populations[J].Bone,2012,50(5):1115-1122.doi: 10.1016/j.bone.2012.01.025
  • [11] KENNEDY O D,LAUDIER D M,MAJESKA R J,et al.Osteocyte Apoptosis is Required for Production of Osteoclastogenic Signals Following Bone Fatigue in Vivo[J].Bone,2014,64:132-137.doi: 10.1016/j.bone.2014.03.049
  • [12] BURR D B.Repair Mechanisms for Microdamage in Bone[J].J Bone Miner Res,2014,29(12):2534-2536.doi: 10.1002/jbmr.2366
  • [13] SEREF-FERLENGEZ Z,BASTA-PLJAKIC J,KENNEDY O D,et al.Structural and Mechanical Repair of Diffuse Damage in Cortical Bone in Vivo[J].J Bone Miner Res,2014,29(12):2537-2544.doi: 10.1002/jbmr.2309
  • [14] LAMBERS F M,BOUMAN A R,RIMNAC C M,et al.Microdamage Caused by Fatigue Loading in Human Cancellous Bone:Relationship to Reductions in Bone Biomechanical Performance[J].PLOS ONE,2014,8(12):e83662.doi:10.1371/journal.pone.0083662
  • [15] DAFFNER R H,PAVLOV H.Stress Fractures:Current Concepts[J].Am J Roentgen,1992,159(2):245-252.
  • [16] 李展春,戴力扬.骨微损伤与骨重建[J].创伤外科杂志,2009(6):568-571.
  • [17] 戴如春,廖二元,杨川,等.应用多元线性回归分析探讨骨微损伤的间接判定方法[J].中国骨质疏松杂志,2003(4):22-26.
  • [18] MARX R G,SAINT-PHARD D,CALLAHAN L R,et al.Stress Fracture Sites Related to Underlying Bone Health in Athletic Females[J].Clinical Journal of Sports Medicine,2001,11(2):73-76.
  • [19] LEE T C,MOHSIN S,TAYLOR D,et al.Detecting Microdamage in Bone[J].Journal of Anatomy,2003,203(2):161-172.doi: 10.1046/j.1469-7580.2003.00211.x
  • [20] ZARRINKALAM K H,KULIWABA J S,MARTIN R B,et al.New Insights into the Propagation of Fatigue Damage in Cortical Bone Using Confocal Microscopy and Chelating Fluorochromes[J].European Journal of Morphology,2005,42(1/2):81-90.
  • [21] LI J L,MILLER M A,HUTCHINS G D,et al.Imaging Bone Microdamage in Vivo with Positron Emission Tomography[J].Bone,2005,37(6):819-824.doi:10.1016/j.bone.2005.06.022
  • [22] LANDRIGAN M D,LI J,TURNBULL T L,et al.Contrast-enhanced Micro-computed Tomography of Fatigue Microdamage Accumulation in Human Cortical Bone[J].Bone,2011,48(3):443-450.doi:10.1016/j.bone.2010.10.160
  • [23] 马育林,戴如春,廖二元.骨微损伤、骨重建与代谢性骨病[J].国际病理科学与临床杂志,2007(6):525-529.
  • [24] TAN S H S,SASEENDAR S,TAN B H M,et al.Ulnar Fractures with Bisphosphonate Therapy:A Systematic Review of Published Case Reports[J].Osteoporosis International,2015,26(2):421-425.doi:10.1007/s00198-014-2885-0
  • [25] PAZIANAS M,KIM S M,YUEN T,et al.Questioning the Association Between Bisphosphonates and Atypical Femoral Fractures[J].MARROW,2015,1335:1-9.doi: 10.1111/nyas.12551
  • [26] O'NEAL J M,DIAB T,ALLEN M R,et al.One Year of Alendronate Treatment Lowers Microstructural Stresses Associated with Trabecular Microdamage Initiation[J].Bone,2010,47(2):241-247.doi:10.1016/j.bone.2010.05.016
  • [27] SHI X,LIU X S,WANG X,et al.Effects of Trabecular Type and Orientation on Microdamage Susceptibility in Trabecular Bone[J].Bone,2010,46(5):1260-1266.doi: 10.1016/j.bone.2010.02.005
  • [28] SLOAN A V,MARTIN J R,LI S.Parathyroid Hormone and Bisphosphonate Have Opposite Effects on Stress Fracture Repair.Bone,2010,47(2):235-240.doi:10.1016/j.bone.2010.05.015
  • [29] TAKEDA S,SMITH S Y,TAMURA T,et al.Long-term Treatment with Eldecalcitol (1 alpha,25-dihydroxy-2 beta-(3-hydroxypropyloxy) Vitamin D-3) Suppresses Bone Turnover and Leads to Prevention of Bone Loss and Bone Fragility in Ovariectomized Rats[J].Calcified Tissue International,2015,96(1):45-55.doi: 10.1007/s00223-014-9937-5
  • [30] SAITO M,GRYNPAS M D,BURR D B,et al.Treatment with Eldecalcitol Positively Affects Mineralization,Microdamage,and Collagen Crosslinks in Primate Bone[J].Bone,2015,73:8-15.doi: 10.1016/j.bone.2014.11.025
  • [31] 刘淑仪,钟晓峰,胡年宏.骨微损伤最新研究及中医药研究进展[J].中国骨质疏松杂志,2013,12:1307-1310.doi:10.3969/j.issn.1006-7108.2013.12.024
  • [32] 叶喜阳,潘晓华,庞春萍,等.淫羊藿黄酮治疗骨质疏松的动物实验研究[J].河北师范大学学报(自然科学版),2010,34(4):468-470.doi:10.3969/j.issn.1000-5854.2010.04.022
  • [33] 魏合伟,林一峰,曲崇正,等.中药骨康含药血清对骨质疏松性骨折愈合过程中血小板衍生生长因子表达的影响[J].中国组织工程研究与临床康复,2008,37:7290-7293.
  • [34] FROST H M.Presence of Microscopic Cracks in Vivo in Bone[J].Henry Ford Hosp Med Bull,1960,8:25-35.
  • [35] HERMAN B C,CARDOSO L,MAJESKA R J,et al.Activation of Bone Remodeling After Fatigue:Differential Response to Linear Microcracks and Diffuse Damage[J].Bone,2010,47:766-772.doi:10.1016/j.bone.2010.07.006
  • [36] FAZZALARI N L,FORWOOD M R,MATHEY B A,et al.Three-dimensional Confocal Images of Microdamage in Cancellous Bone[J].Bone,1998,23(4):373-378.doi:10.1016/S8756-3282(98)00111-2
  • [37] 王瑞,曹永平.骨微损伤及其修复[J].中华骨质疏松和骨矿盐疾病杂志,2011(2):116-121.doi:10.3969/j.assn.1674-2591.2011.02.009
  • [38] CHAPURLAT R D,DELMAS P D.Bone Microdamage:A Clinical Perspective[J].Osteoporosis International,2009,20(8):1299-1308.doi:10.1007/s00198-009-0899-9
  • [39] BOYCE T M,FYHRIE D P,RADIN E L,et al.Damage Type and Strain Mode Associations in Human Compact Bone Bending Fatigue[J].Journal of Orthopaedic Research,1998,16(3):322.doi:10.1002/jor.1100160308
  • [40] REILLY G C,CURREY J D.The Development of Microcracking and Failure in Bone Depends on the Loading Mode to Which It Is Adapted[J].J Exper Biol,1999,202:543-552.
  • [41] ARLOT M E,BURT-PICHAT B,ROUX J P,et al.Microarchitecture Influences Microdamage Accumulation in Human Vertebral Trabecular Bone[J].Journal of Bone and Mineral Research,2008,23(10):1613-1618.doi: 10.1359/JBMR.080517

版权所有 2013-2021 河北师范大学学报编辑部 地址：河北省石家庄市南二环东路20号

邮编：050024 电话：0311-80786360 技术支持：载驰科技