河北师范大学学报—

期刊信息

刊名：河北师范大学学报（自然科学版）Journal of Hebei Normal University (Natural Science)
主办：河北师范大学
ISSN： 1000-5854
CN： 13-1061/N
中国科技核心期刊
中国期刊方阵入选期刊
中国高校优秀科技期刊
华北优秀期刊
河北省优秀科技期刊

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钾离子及钾通道在细胞凋亡时线粒体变化中的作用

周娜静^1,2

闫蕴力¹

张海林²

1. 河北医科大学基础医学院细胞生物研究室, 河北石家庄 050017;
2. 河北医科大学基础医学院药理教研室, 河北石家庄 050017
DOI： 10.13763/j.cnki.jhebnu.nse.2015.05.015

Effect of Potassium and Potassium Channels on Mitochondria During Apoptosis

ZHOU Najing^1,2, YAN Yunli¹, ZHANG Hailin²

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摘要/Abstract

摘要：

细胞凋亡在多种生命活动及疾病中均具有重要作用,线粒体是决定细胞凋亡的关键因素.近年研究发现,细胞内高钾可以保护细胞免于凋亡.但也有研究表明,钾离子及钾离子通道可参与线粒体的结构和功能改变,影响细胞凋亡.明确细胞内钾离子对线粒体的影响,可以更好的理解细胞凋亡及其相关的多种生理、病理机制.综述了钾离子及钾离子通道在细胞凋亡时对线粒体的作用.

Abstract：

Apoptosis participates in many physiological and pathological processes,and mitochondria is a key factor in apoptosis.Recently,researchers have found that high cytosolic potassium concentration can protect cells against apoptosis.However,other studies report that potassium and potassium channels are involved in mitochondria regulation and affect apoptosis.Investigating the effect of potassium and potassium channels on mitochondria will provide insights into the mechanism of apoptosis and the related physiological or pathological processes.This paper reviews the effect of potassium and potassium channels on mitochondria during the process of apoptosis.

关键词

关键词： 钾离子 ; 钾通道 ; 细胞凋亡 ; 线粒体

Key words： potassium ; potassium channels ; apoptosis ; mitochondria

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