期刊信息
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- 刊名: 河北师范大学学报(哲学社会科学版)Journal of Hebei Normal University (Philosophy and Social Sciences Edition)
- 主办: 河北师范大学
- ISSN: 1000-5587
- CN: 13-1029/C
- 该刊被以下数据库收录:
- AMI综合评价(A刊)核心期刊
- RCCSE中国核心学术期刊
- 中国期刊方阵入选期刊
- 全国百强社会科学学报
- 中国人民大学“复印报刊资料”重要转载来源期刊
槲皮素对2型糖尿病患者机体铁代谢的影响
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作者单位:
河北师范大学 体育学院, 河北 石家庄 050024 -
起止页码:
272 - 276页
Effect of Quercetin on Iron Metabolism in Type 2 Diabetes
摘要/Abstract
2型糖尿病(T2DM)主要是由于胰岛素抵抗或机体代谢紊乱所导致的一种慢性疾病.铁是人体中不可或缺的一种微量元素,对维持机体的正常生理功能非常重要.研究表明,铁过载是T2DM的诱因之一.槲皮素是一种天然的黄酮化合物,能够螯合机体内的铁,而且具有抗氧化、抗炎症、增强胰岛素敏感性等作用.系统阐述了T2DM与铁代谢、槲皮素的关系,为T2DM的防治提供理论依据.
Type 2 diabetes mellitus (T2DM) is a kind of chronic disease that results from insulin resistance or metabolic disorder. Iron is a kind of indispensable trace element and is very important to maintain the normal physiological function in our body. Recent studies show that iron overload is one of the causes of T2DM. Quercetin is a kind of natural flavonoid compound. The beneficial effects of quercetin are associated not only with antioxidant and anti-inflammatory but also with chelation of iron in the body. This paper intends to provide theoretical basis for the treatment of T2DM by elaborating the relationship between T2DM and iron overload, and the relationship between quercetin and T2DM.
关键词
参考文献 38
- [ 1 ] KANETO H,KATAKAMI N,MATSUHISA M,et al.Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis[J].Mediators Inflamm,2010,2010(1):453892.doi:10.1155/2010/453892
- [ 2 ] MALLAT N S,MALLAT S G,MUSALLAM K M,et al.Potential Mechanisms for Renal Damage in Beta-thalassemia[J].J Nephrol,2013,26(5):821-828.doi:10.5301/in.5000253
- [ 3 ] WILSON J G,LINDQUIST J H,GRAMBOW S C,et al.Potential Role of Increased Iron Stores in Diabetes[J].Am J Med Sci,2003,325(6):332-339.doi:10.1097/00000441-200306000-00004
- [ 4 ] ZIMMERMANN M B,HURRELL R F.Nutritional Iron Deficiency[J].Lancet,2007,370(9586):511-520.doi:10.1016/S0140-6736(07)61235-5
- [ 5 ] OATES P S.The Role of Hepcidin and Ferroportin in Iron Absorption[J].Histol Histopathol,2007,22(7):791-804.doi:10.1016/S0140-6736(07)6123535-5
- [ 6 ] 高蔚娜,郭长江,韦京豫,等.槲皮素对氧化应激大鼠肝细胞的保护作用[J].中华临床营养杂志,2007,15(4):209-213.doi:10.3760/cma.j.issn.1674-635X.2007.04.003
- [ 7 ] 宋玉乔,姚凌云,曹蔚,等.槲皮素的药理作用研究近况[J].西北药学杂志,2002,17(1):40-42.doi:10.3969/j.issn.1004-2407.2002.01.028
- [ 8 ] OLIVA J,BARDAG-GORCE F,TILLMAN B,et al.Protective Effect of Quercetin,EGCG,Catechin and Betaine Against Oxidative Stress Induced by Ethanol in Vitro[J].Exp Mol Pathol,2011,90(3):295-299.doi:10.1016/i.yexmp.2011.02.006
- [ 9 ] YAO P,NUSSLER A,LIU L,et al.Quercetin Protects Human Hepatocytes from Ethanol-derived Oxidative Stress by Inducing Heme Oxygenase-1 via the MAPK/Nrf2 Pathways[J].J Hepatol,2007,47(2):253-261.doi:10.1016/J.JHEP.2007.02.008
- [ 10 ] CHOUGALA M B,BHASKAR J J,RAJAN M G,et al.Effect of Curcumin and Quercetin on Lysosomal Enzyme Activities in Streptozotocin-induced Diabetic Rats[J].Clin Nutr,2012,31(5):749-755.doi:10.1016/J/clnu.2012.02.003
- [ 11 ] PUNITHAVATHI V R,PRINCE P S.Pretreatment with a Combination of Quercetin and Alpha-tocopherol Ameliorates Adenosine Triphosphatases and Lysosomal Enzymes in Myocardial Infarcted Rats[J].Life Sci,2010,86(5/6):178-184.doi:10.1016/J.lfs.2009.11.021
- [ 12 ] LEE T I,KAO Y H,CHEN Y C,et al.Oxidative Stress and Inflammation Modulate Peroxisome Proliferator-activated Receptors with Regional Discrepancy in Diabetic Heart[J].Eur J Clin Invest,2010,40(8):692-699.doi:10.1111/j.1365-2362.20100.02318.X
- [ 13 ] AIGNER E,FELDMAN A,DALI C.Obesity as an Emerging Risk Factor for Iron Deficiency[J].Nutrients,2014,6(9):3587-3600.doi:10.3390/nu6093587
- [ 14 ] LI Y,CHEN M,XU Y,et al.Iron-mediated Lysosomal Membrane Permeabilization in Ethanol-induced Hepatic Oxidative Damage and Apoptosis:Protective Effects of Quercetin.[J].Oxid Med Cell Longev,2016,2016:4147610.doi:10.1155/201614147610
- [ 15 ] FERNANDEZ-REAL J M,LOPEZ-BERMEJO A,RICART W.Cross-talk Between Iron Metabolism and Diabetes[J].Diabetes,2002,51(8):2348-2354.doi:10.2337/diabetes.51.8.2348
- [ 16 ] BERDOUKAS V,COATES T D,CABANTCHIK Z I.Iron and Oxidative Stress in Cardiomyopathy in Thalassemia[J].Free Radic Biol Med,2015,88(Pt A):3-9.doi:10.1016.freeradbiomed,2015.07.019
- [ 17 ] 逄金柱.线粒体解偶联蛋白3的生理作用及影响其表达因素的研究[D].北京:北京体育大学,2016.
- [ 18 ] BERDOUKAS V,COATES T D,CABANTCHIK Z I.Iron and Oxidative Stress in Cardiomyopathy in Thalassemia[J].Free Radic Biol Med,2015,88(Pt A):3-9.doi:10.1016.freeradbiomed.2015.07.019
- [ 19 ] EATON J W,QIAN M.Molecular Bases of Cellular Iron Toxicity[J].Free Radic Biol Med,2002,32(9):833-840.doi:10.1016/S0891-5849(02)00772-4
- [ 20 ] BAO W,CHAVARRO J E,TOBIAS D K,et al.Long-term Risk of Type 2 Diabetes in Relation to Habitual Iron Intake in Women with a History of Gestational Diabetes:A Prospective Cohort Study[J].Am J Clin Nutr,2016,250(16):2178-2179.doi:10.3945/ajcn.115.108712
- [ 21 ] TORMOS K,ANSO E,HAMANAKA R,et al.Mitochondrial Complex Ⅲ ROS Regulate Adipocyte Differentiation[J].Cell Metab,2011,14(4):537-544.doi:10.1016.J.cmet.2011.02.007
- [ 22 ] RAY P D,BO-WEN H,YOSHIAKI T.Reactive Oxygen Species (ROS) Homeostasis and Redox Regulation in Cellular Signaling.[J].Cell Signal,2012,24(5):981-990.doi:10.10116.cellsi.2012.01.008
- [ 23 ] 胡银平,李立卓,王金霞,等.运动防治2型糖尿病的铁调控机制研究进展[J].现代预防医学,2015,42(17):3236-3238.
- [ 24 ] FERNANDZ-REAL J M,RICART-ENGEL W,ARROYO E,et al.Serum Ferritin as a Component of the Insulin Resistance Syndrome[J].Diabetes Care,1998,21(1):62-68.doi:10.2337/diacare.21.1.62
- [ 25 ] VALENTI L,FRACANZANI A L,DONGIOVANNI P,et al.Iron Depletion by Phlebotomy Improves Insulin Resistance in Patients with Nonalcoholic Fatty Liver Disease and Hyperferritinemia[J].Am J Gastroenterol,2007,102(6):1251-1258.doi:10.1111/J,1572-0241.2007.01192.X
- [ 26 ] FORD E S,COGSWELL M E.Diabetes and Serum Ferritin Concentration Among US Adults[J].Diabetes Care,1999,22(12):1978-1983.doi:10.2337/diacare.22.12.1978
- [ 27 ] ALAM M M,MEERZA D,NASEEM I.Protective Effect of Quercetin on Hyperglycemia,Oxidative Stress and DNA Damage in Alloxan Induced Type 2 Diabetic Mice[J].Life Sci,2014,109(1):8-14.doi:10.1016/j.lfs.2014.06.005
- [ 28 ] SANTOS J M,RIBEIRO S B,GAYA A R,et al.Skeletal Muscle Pathways of Contraction-enhanced Glucose Uptake[J].Int J Sports Med,2008,29(10):785-794.doi:10.1055/S2008-1038404
- [ 29 ] LETO D,SALTIEL A R.Regulation of Glucose Transport by Insulin:Traffic Control of GLUT4[J].Nat Rev Mol Cell Biol,2012,13(6):383-396.doi:10.1038/NRM3351
- [ 30 ] 张建华.槲皮素对高脂诱导NAFLD大鼠肝损伤的保护作用及其机制的研究[D].南京:南京大学,2016.
- [ 31 ] WARD N C,SHEN Y,HODGSON J M,et al.Quercetin and Its Metabolites Improve Vessel Function by Inducing ENOS Activity via Activation of AMPK[J].Biochem Pharmacol,2012,53(8):1036-1044.doi:10.1016/J.bcp.2012.07.016
- [ 32 ] XU M,HU J,ZHAO W,et al.Quercetin Differently Regulates Insulin-mediated Glucose Transporter 4 Translocation Under Basal and Inflammatory Conditions in Adipocytes[J].Mol Nutr Food Res,2014,58(5):931-941.doi:10.1002/mnfr.2013.00510
- [ 33 ] 王雪.嗜酸乳杆菌对Ⅱ型糖尿病小鼠预防与治疗效果的研究[D].大连:大连医科大学,2010.doi:10.7666/d.y2028396
- [ 34 ] 石立,李德,汤晓强,等.肥胖糖尿病患者腹内脂肪含量与脂肪细胞因子、胰岛素抵抗相关性研究[J].实用临床医药杂志,2016,20(21):38-40.doi:10.7619/jcmp.201621012
- [ 35 ] LONGUET C,BROCA C,COSTES S,et al.Extracellularly Regulated Kinases 1/2(p44/42 Mitogen-activated Protein Kinases) Phosphorylate Synapsin Ⅰ and Regulate Insulin Secretion in the MIN6 Beta-cell Line and Islets of Langerhans[J].Endocrinology,2013,146(2):643-654.doi:10.1210/en.2004-0841
- [ 36 ] LEOPOLDINI M,RUSSO N,CHIODO S,et al.Iron Chelation by the Powerful Antioxidant Flavonoid Quercetin.[J].Agric Food Chem,2006,54(17):6343-6351.doi:10.1021/jf.060986h
- [ 37 ] KAZUTOSHI M,SHIGEYUKI A,SATOKO U,et al.Involvement of Splenic Iron Accumulation in the Development of Nonalcoholic Steatohepatitis in Tsumura Suzuki Obese Diabetes Mice[J].Sci Rep,2016,6:22476.doi:10.1038/SREP.22476
- [ 38 ] TANG Y,LI Y,YU H,et al.Quercetin Attenuates Chronic Ethanol Hepatotoxicity[J].Food Chem Toxicol,2014,67(3):131-138.doi:10.1016/fct.20.022