在线阅读 --自然科学版 2009年3期《铽-α-萘甲酸-邻菲啰啉三元配合物的抗菌效果》
铽-α-萘甲酸-邻菲啰啉三元配合物的抗菌效果--[在线阅读]
张雪梅1, 田莉瑛1, 杨楠2, 赵宝华2
1. 河北化工医药职业技术学院化学与环境工程系, 河北石家庄 050026;
2. 河北师范大学生命科学学院, 河北石家庄 050016
起止页码: 374--376页
DOI:
摘要
采用滤纸片法测定了铽-α-萘甲酸-邻菲啰啉三元配合物、铽元素、α-萘甲酸、phen的抗菌性.结果表明:铽-α-萘甲酸-邻菲口罗啉配合物的抑菌性大于配体邻菲啰啉、α-萘甲酸、铽元素;稀土配合物的抗菌性存在浓度效应;配合物对6种测试菌的抑制性顺序为大肠埃希氏菌>酿酒酵母>枯草芽胞杆菌>表皮葡萄球菌>金黄色葡萄球菌>铜绿假单胞杆菌.对铽-α-萘甲酸-邻菲啰啉稀土配合物抑菌谱的研究有助于稀土配合物抑菌机理的探索.

Study on the Antibacterial Effects of Ternary Complex Tb(α-NMA) 3phen·H-O
ZHANG Xue-mei1, TIAN Li-ying1, YANG Nan2, ZHAO Baohua2
1. Department of Chemistry and Environmental Engineering, Hebei Chemical andPharmaceutical Vocational Technology College, Hebei Shijiazhuang 050026, China;
2. College of Life Science, Hebei Normal University, Hebei Shijiazhuang 050016, China
Abstract:
The antibacterial effect s of Tb-α-NMA-phen, Tb,α-NMA and phen were investigated with paper dish diffusion method. The result s showed that the antibacterial effect of the rare earth complex was much better thanα-NMA,phen and Tb. There existed a dosage-dependence in the antibacterial effect of the rare earth complex. The antibacterial effect of the rare earth complex on the six strains was in the order as E. coli > S. cerevisiae > B. subtill > S. epidermidis > S. aureus > P. aerugi nosa. The research on antibacterial spect rum of RE complex was useful for investigating antibacterial mechanism.

收稿日期: 2008-9-1
基金项目: 国家自然科学基金(20773034)

参考文献:
[1]HE Qi2zhuang,YANGJing,MIN Hui,et al. Studies on the Spectra and Antibacterial Properties of Rare Earth Dinuclear Com2 plexes with L2phenylalanine and O2phenanthroline [J]. Materials Letters,2006, (60) :317-320.
[2]何其庄,郁慧,周美峰,等. 稀土天冬氨酸邻菲咯啉三元配合物的合成、表征及其生物活性研究[J]. 中国稀土学报,2007, 25 (2) :150-151.
[3]宋玉民,董银龙,付云龙,等. 稀土与华法灵、水杨酸三元配合物的合成和抗凝血作用研究[J]. 化学学报,2007,65 (8) :36-40.
[4]L IU J,MEI WJ,XU A W. Synthesis,Characterization and Antiviral Activity Against Influenza Virus of a Series of Novel Manganese-substituted Rare Earth Borotungstates Heteropolyoxometalates [J]. Antiviral Res,2004,62 (1) :65-71.
[5]KOSTOVA I,MOMEKOV G,TZANOVA T,et al. Synthesis,Characterization,and Cytotoxic Activity of New Lanthanum(Ⅲ) Complexes of Bis2coumarins [J].Bioinorg Chem Appl,2006, (20) :1-9.
[6]SHI P,HUANG Z. Proteomic Detetion of Changes in Protein Synthesis Induced by Lanthanum in BGC-823 Human Gastric Cancer Cells [J].Biometals,2005,18 (1) :89-95. Study