在线阅读 --自然科学版 2011年3期《1,4-二(氯乙酰基)哌嗪的合成》
1,4-二(氯乙酰基)哌嗪的合成--[在线阅读]
王娟, 岳红坤, 刘占荣, 贾鹏飞
石家庄学院化工学院, 河北石家庄 050035
起止页码: 283--285页
DOI:
摘要
以无水哌嗪和氯乙酰氯为主要起始原料,无水碳酸钠为缚酸剂,水为溶剂,经酰化反应得到1,4-二(氯乙酰基)哌嗪,并对反应的工艺参数进行了优化.最佳反应条件是:n(无水哌嗪)∶n(氯乙酰氯)=1∶2.2,反应温度-6℃,反应60 min,产品收率为83.9%,经<>sup1HnMR和MS分析确定产品结构与目标产物相符.

Synthesis of 1,4bis(chloroacetyl)piperazine
WANG Juan, YUE Hongkun, LIU Zhanrong, JIA Pengfei
School of Chemical Engineering, Shijiazhuang University, Hebei Shijiazhuang 050035, China
Abstract:
1,4-bis(chloroacetyl)piperazine was prepared from anhydrous piperazine and chloroacetyl chloride using water as solvent in the presence of anhydrous sodium carbonate.Technological parameters involved in this reaction were optimized.Under the optimized conditions:the molar ratio of anhydrous piperazine and chloroacetyl chloride was 1∶2.2,reaction temperature-6 ℃,reaction time 60 min,the yield counting with anhydrous piperazine was 83.9 %.The product structure was conformed to target product through<>sup1HNMR and MS analysis and determination.

收稿日期: 2010-7-13
基金项目: 石家庄市科技局科学技术研究与发展指导计划基金(09107481);石家庄学院博士基金(2009003)

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