在线阅读 --自然科学版 2020年6期《呋喃并[3,2b]吡啶衍生物的高效合成》
呋喃并[3,2b]吡啶衍生物的高效合成--[在线阅读]
范威
滁州城市职业学院 医学系, 安徽 滁州 239000
起止页码: 516--520页
DOI: 10.13763/j.cnki.jhebnu.nse.2020.06.009
摘要
以取代的查尔酮环氧化物和呋喃酮为原料,乙二醇为溶剂,在碳酸铯促进下通过去质子、亲核取代、氢转移、分子内Knoevenagel缩合等过程,合成了呋喃并[3,2b]吡啶衍生物,单晶衍射分析证实了产物结构.该反应为大量合成呋喃并[3,2b]吡啶化合物提供了有效的方法.

Efficient Synthesis of Furo[3,2b]pyridine Derivatives
FAN Wei
Department of Medicine, Chuzhou City Vocation College, Anhui Chuzhou 239000, China
Abstract:
Using substituted chalcone epoxide and furanone as raw materials, ethylene glycol as solvent, under the promotion of cesium carbonate, furo[3,2b]pyridines were synthesized through deprotonation,nucleophilic substitution,hydrogen transfer,and intramolecular Knoevenagel condensation,etc.The structures of products were confirmed by the single crystal X-ray diffraction.This reaction provided an effective method for the synthesis of furo[3,2b]pyridines in large quantities.

收稿日期: 2020-04-26
基金项目: 滁州城市职业学院重点项目(2019jyxm02);滁州城市职业学院院级科研项目(2020ZK03,2020ZK05)

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