在线阅读 --自然科学版 2016年6期《杀真菌剂唑菌酮的合成》
杀真菌剂唑菌酮的合成--[在线阅读]
李文燕1, 刘洪涛2, 庞国勋2, 谷晨曦1, 王翠平1, 刘彩霞1
1. 河北师范大学 化学与材料科学学院, 河北 石家庄 050024;
2. 河北省人民医院 药学部, 河北石 家庄 050051
起止页码: 523--525页
DOI: 10.13763/j.cnki.jhebnu.nse.2016.06.012
摘要
以二苯醚与丙酮酸乙酯为原料,经傅克酰基化一步合成关键中间体2-(4-苯氧基苯基)乳酸乙酯,再与羰基二咪唑、苯肼一锅法合成杀真菌剂唑菌酮,总收率为72.5%.

Synthesis of Fungicide Famoxadone
LI Wenyan1, LIU Hongtao2, PANG Guoxun2, GU Chenxi1, WANG Cuiping1, LIU Caixia1
1. College of Chemistry and Material Sciences, Hebei Normal University, Hebei Shijiazhuang 050024, China;
2. Department of Pharmacy, Hebei General Hospital, Hebei Shijiazhuang 050051, China
Abstract:
The key intermediate of famoxadone ethyl 2-(4-phenoxyphenyl)lactate was synthesized by Friedel-Crafts acylation using diphenyl oxide and ethyl pyruvate as raw materials.Subsequently,treatment of ethyl 2-(4-phenoxyphenyl) lactate with N,N'-carbonyldiimidazole and phenylhydrazine obtained famoxadone by one-pot reaction.The total yield was 72.5%.

收稿日期: 2015-11-30
基金项目: 河北师范大学青年科学基金(L2013Q02);河北师范大学大学生课外学术科技创新项目(CD201591992536)

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