在线阅读 --自然科学版 2016年4期《SIRT1在运动防治糖尿病患者骨骼肌胰岛素抵抗中的作用》
SIRT1在运动防治糖尿病患者骨骼肌胰岛素抵抗中的作用--[在线阅读]
杨雯茜1, 杨光1, 郑梅2, 刘玉倩1, 王海涛1
1. 河北师范大学 体育学院, 河北 石家庄 050024;
2. 石家庄市第一医院, 河北 石家庄 050011
起止页码: 362--368页
DOI: 10.13763/j.cnki.jhebnu.nse.2016.04.014
摘要
沉默交配型信息调节因子2同源蛋白1(SIRT1)是NAD+依赖的组蛋白去乙酰化酶,参与葡萄糖/脂质代谢、线粒体生物合成、炎症、自噬和生理节律等.最近研究表明,SIRT1在糖尿病发病中发挥重要作用,糖尿病发病率升高与饮食结构的改变和久坐的生活方式密切相关,运动可以通过SIRT1介导的调控通路改善糖尿病患者骨骼肌的胰岛素敏感性,降低胰岛素抵抗.概括了近几年腺苷酸活化蛋白激酶(AMPK),SIRT1,过氧化物酶体增殖物激活受体γ协同刺激因子1α(PGC-1α)在运动防治糖尿病中的研究现状及发展趋势,为通过运动改善骨骼肌代谢功能防治糖尿病提供新的思路.

Role of SIRT1 Plays to Prevent Insulin Resistance of Skeletal Muscle by Exercise in Diabetic Patients
YANG Wenqian1, YANG Guang1, ZHENG Mei2, LIU Yuqian1, WANG Haitao1
1. Department of Physical Education, Hebei Normal University, Hebei Shijiazhuang 050024, China;
2. The First Hospital of Shijiazhuang City, Hebei Shijiazhuang 050011, China
Abstract:
Silent mating type information regulation 2 homolog (SIRT1) is a kind of NAD+-dependent histone deacetylase.It is involved in the glucose/lipid metabolism,mitochondrial biosynthesis,inflammation,autophagy and circadian rhythm,etc.Recent studies have shown that SIRT1 plays a significant role in the incidence of diabetes.The incidence of diabetes is closely related to the diet and sedentary lifestyle.Exercise can be mediated by SIRT1 regulation pathways to improve diabetes skeletal muscle insulin sensitivity and decrease insulin resistance.This paper summarized the research status and development trend of recent years that adenosine 5'-monophosphate-activated protein kinase(AMPK),SIRT1,peroxisome proliferator-activated receptor-γ coactivator-1α(PGC-1α) alpha in preventing and controlling of diabetes with exercise,and provides new mentality about improving skeletal muscle metabolism,and prevention and treatment of diabetes through exercise.

收稿日期: 2015-10-13
基金项目: 河北省自然科学基金(C2013205026);河北省教育厅重点基金(ZD20131100);河北师范大学重点基金(L2013Z08);河北省体育教育训练学重点学科资助;河北师范大学体育学重点学科;2016年院研究生创新资助

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